Mofezolac

SKU: orb1301773

Description

Mofezolac is a highly selective COX-1 inhibitor, formerly known as Disopain or N-22, with a COX selectivity index exceeding 6000. It is a valuable research tool for investigating COX-1-specific roles in inflammation and pain mechanisms in both in vitro and in vivo experimental models.

Research Area

Immunology & Inflammation, Neuroscience

Key Properties

• CAS Number: 78967-07-4
• MW: 339.34
• Purity: 99.29% (May vary between batches)
• Formula: C₁₉H₁₇NO₅
• SMILES: COc1ccc(cc1)-c1noc(CC(O)=O)c1-c1ccc(OC)cc1
• Target: COX
• Solubility: Ethanol:Insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.89 mM);H2O:Insoluble;DMSO:55 mg/mL (162.08 mM)

Bioactivity

• Target IC50:
  COX-2:447 nM (IC50)|COX-1:1.44 nM (IC50)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

aggregation, anti-inflammatory, analgesic, COX, COX-1, Cyclooxygenase, Inhibitor, pain, Mofezolac, inhibit, NSAID, platelet

Compound Identifiers

PubChem CID

4237