Modzatinib

SKU: orb3135176

Description

Modzatinib (ITKkinase-IN-1) (compound I) is an inhibitor targeting ITK kinase with an IC50 of 8 nM in Jurkat cells, useful for researching inflammatory diseases. Modzatinib (ITKkinase-IN-1) (compound I) inhibits JAK3 in hPBMC cells with an IC50 of 23 nM (based on IL-2/pSTAT5 levels) and shows no inhibitory effect on JAK2. Modzatinib (ITKkinase-IN-1) (compound I) is therefore applied in immunological signaling research to study T-cell receptor–associated kinase pathways, JAK/STAT signaling selectivity, and cytokine response modulation in primary immune cell systems.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2411407-25-3
• MW: 361.39
• Purity: 99.15% (May vary between batches)
• Formula: C₁₈H₂₁F₂N₅O
• SMILES: N(C1=C2C(=CNC2=NC=N1)[C@@H]3C(F)(F)C3)[C@H]4CN(C(C=C)=O)[C@@H](C)CC4
• Target: Tyrosine Kinases,JAK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Tyrosine Kinases,JAK