Moclobemide

SKU: orb1224169

Description

Moclobemide(Ro111163) is a reversible monoamine oxidase inhibitor (MAOI) selective for isoform A (RIMA) used to treat major depressive disorder.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 71320-77-9
• MW: 268.74
• Purity: >98% (HPLC)
• Formula: C₁₃H₁₇ClN₂O₂
• SMILES: O=C(NCCN1CCOCC1)C2=CC=C(Cl)C=C2
• Target: MAO
• Solubility: Ethanol: 10 mg/mL (37.21 mM); DMSO: 53 mg/mL (197.21 mM)

Bioactivity

• In Vivo:
  Moclobemide is a monoamine oxidase inhibitor and increases the levels of brain monoamines (such as 5-HT, norepinephrine). Moclobemide(40 mg/kg) is effective in animal behavior models. Animal model: Chronically stressed male mice (18±2 g) of the Kunming strain. Dosage: 40 mg/kg. Administration: i.p.; daily. Result: BDNF level in the hippocampal subfields including subgranule zone decreased in stressed mice compared with normal control. Chronic treatment with Moclobemide could reverse these changes.
• In Vitro:
  NMDA (600 μM for 3 days) inhibits the proliferation of PC12 cells. Moclobemide (2 and 10 μM) up-regulates the proliferation in NMDA-treated PC12 cells. Cell Cycle Analysis Cell line: PC12 cell line. Concentration: Moclobemide (2 and 10 μM); N-methylaspartate (NMDA) (600 μM). Incubation time: 3 days. Result: Treatment with NMDA significantly reduced the percentage of S-phase, while the percentage of other cell cycle phases did not change notablely. However, the percentage of S-phase increased in the presence of Moclobemide.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ro 11-1163

Quick Database Links

Gene Symbol

MAO