MO-2097

SKU: orb3141846

Description

MO-2097 is an inhibitor of RAF-1 and HIF-1α. It destabilizes RAF-1, reducing EMT-related transcription factors and mesenchymal markers. MO-2097 suppresses HIF-1α protein expression under hypoxic or hypoxia-mimicking conditions via hnRNPA2B1. It induces mitochondrial ROS production, leading to cell apoptosis. By inhibiting the RAF/MEK/ERK signaling pathway, MO-2097 effectively prevents colorectal cancer metastasis. It also inhibits tumor growth in human colorectal cancer HCT116 cell xenograft mouse models. MO-2097 is applicable for colorectal cancer research.

Key Properties

• CAS Number: 2744300-63-6
• MW: 308.33
• Formula: C₁₉H₁₆O₄
• SMILES: OC=1C=C(O)C=C(C1)C=2OC=3C=C4OCC(=CCC4=CC3C2)C
• Target: Apoptosis,Caspase,ROS,HIF/HIF Prolyl-Hydroxylase,MEK,Raf,ERK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,Caspase,ROS,HIF/HIF Prolyl-Hydroxylase,MEK,Raf,ERK