MN58b

SKU: orb1309405

Description

MN58b is a potent and selective small molecule inhibitor of choline kinase alpha (CHKα). It is a valuable research tool for studying choline metabolism in oncology, with applications in both cell-based assays and in vivo models of cancer.

Research Area

Cell Biology, Neuroscience

Key Properties

• CAS Number: 203192-01-2
• MW: 640.49
• Purity: 97.46% (May vary between batches)
• Formula: C₃₂H₄₀Br₂N₄
• SMILES: [Br-].[Br-].CN(C)c1cc[n+](Cc2ccc(CCCCc3ccc(C[n+]4ccc(cc4)N(C)C)cc3)cc2)cc1
• Target: Apoptosis,AChR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.56 mM);DMSO:6.41 mg/mL (10.01 mM)

Bioactivity

• In Vivo:
  MN58b treatment significantly decreases phosphomonoesters in both HT29 and MDA-MB-231 xenografts. Phosphocholine levels are found to correlate with choline kinase activities.
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• In Vitro:
  MN58b (1-5 μM; 72 hours; SK-PC-1, Suit2 008, IMIM-PC2, and RWP-1 cells) has a marked effect on colony formation at 1 μM, and growth is completely abolished at 5 μM in all the cell lines
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, MN58b, MN-58b, Inhibitor, Apoptosis, choline kinase alpha (ChoKα)

Compound Identifiers

PubChem CID

52952144