MN-25

SKU: orb2814664

Description

MN-25 (compound 4a) is an orally bioavailable indole pyridinone acting as a novel cannabinoid receptor ligand, with a binding preference for CB2 (Ki=11 nM) over CB1. It functions as a CB2 agonist, inhibiting TNF-α release in vitro (IC50=33 μM), though it showed no efficacy in a murine acute inflammation model at 50 mg/kg orally. This compound is a research tool for studying CB2 receptor pharmacology in immunomodulation and inflammation.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 501926-82-5
• MW: 439.59
• Formula: C₂₆H₃₇N₃O₃
• SMILES: C(CN1CCOCC1)N2C=3C(C(C(N[C@H]4[C@]5(C)C[C@](C4(C)C)(CC5)[H])=O)=C2)=CC=CC3OC
• Target: Cannabinoid Receptor,TNF

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

71308243