MMP-2/MMP-9 Inhibitor II

SKU: orb1693510

Description

BPHA is a potent, selective, and orally bioavailable inhibitor targeting MMP-2, MMP-9, and MMP-14 with nanomolar IC50 values, while sparing MMP-1, -3, and -7. It exhibits anti-angiogenic and anti-tumor properties, making it a valuable research tool for studying cancer metastasis and angiogenesis in both cellular and animal models.

Research Area

Cancer Biology; Cardiovascular Research; Musculoskeletal & Connective Tissue Research, Protein Biochemistry

Key Properties

• CAS Number: 193807-60-2
• MW: 396.46
• Purity: 99.72% (May vary between batches)
• Formula: C₂₁H₂₀N₂O₄S
• SMILES: S(N[C@H](CC1=CC=CC=C1)C(NO)=O)(=O)(=O)C2=CC=C(C=C2)C3=CC=CC=C3
• Target: MMP
• Solubility: DMSO:90 mg/mL (227.01 mM);Methanol:22.5 mg/mL (56.75 mM)

Bioactivity

• Target IC50:
  MMP1:974 nM|MMP2:12 nM|MMP7:795 nM|MMP9:16 nM|MMP3:>1000 nM|MMP14:17 nM
• In Vivo:
  Administration of BPHA (200 mg/kg; via oral; daily) in mice effectively suppresses tumor-induced angiogenesis, primary tumor growth, and liver metastasis. BPHA exhibits remarkable growth inhibitory activity of 48% and 45% in the B16-BL6 melanoma and F2 hemangio-endothelioma models, respectively.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MMP-9, MMP-2/MMP-9 Inhibitor II, MMP-2, MMP-14, BPHA

Compound Identifiers

PubChem CID

9822095