MMP-2/MMP-9 Inhibitor I

SKU: orb1705030

Description

MMP-2/MMP-9-IN-1 is a potent and selective oral inhibitor of MMP-9 (IC50=0.24 µM) and MMP-2 (IC50=0.31 µM). It is a valuable research tool for investigating the role of type IV collagenases in cancer invasion, metastasis, and angiogenesis in both cellular and animal models.

Research Area

Cancer Biology; Cardiovascular Research; Musculoskeletal & Connective Tissue Research, Protein Biochemistry

Key Properties

• CAS Number: 193807-58-8
• MW: 381.44
• Purity: 99.98% (May vary between batches)
• Formula: C₂₁H₁₉NO₄S
• SMILES: S(N[C@H](CC1=CC=CC=C1)C(O)=O)(=O)(=O)C2=CC=C(C=C2)C3=CC=CC=C3
• Target: MMP
• Solubility: DMSO:180 mg/mL (471.9 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.49 mM)

Bioactivity

• Target IC50:
  MMP9:0.24 μM|MMP2:0.31 μM
• In Vivo:
  Both hydroxamic acid and carboxylic acid analogs of MMP-2/MMP-9 inhibitor I were evaluated for their inhibitory activities in animal cancer models. Results showed that lung colonization of Lewis lung carcinoma cells was suppressed by these inhibitors significantly. In addition, antitumor activity was also observed in the human lung cancer model. Ma44 cells growed as a solid tumor on the peritoneum after being implanted ip, and mice bearing Ma44 eventually died within 3 to 4 weeks. Daily oral administration of compound 5l led to prolonged survival of Ma44-bearing mice.
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• In Vitro:
  MMP-2/MMP-9 inhibitor I was identified as a potent inhibitor of matrix metalloproteinase-2 (MMP-2) and MMP-9 with IC50 values of 310 and 240 nM, respectively. MMP-2/MMP-9 inhibitor I acted by binding zinc at the active site of these MMPs. MMP-2/MMP-9 inhibitor I was found to be able to block MMP-2/MMP-9-dependent invasion in cell culture model.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MMP-2, MMP2/MMP9 Inhibitor I, MMP-2/MMP-9 Inhibitor I, MMP 2/MMP 9 Inhibitor I, MMP-9

Compound Identifiers

PubChem CID

10667540