MMP-12 Inhibitor

SKU: orb1301174

Description

This small molecule is a potent and selective MMP-12 inhibitor, exhibiting IC50 values of 2, 160, 320, and 22.3 nM against the human, mouse, rat, and sheep enzymes, respectively. It is a valuable research tool for studying the role of MMP-12 in inflammatory and fibrotic diseases in both cellular assays and animal models.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 1258003-93-8
• MW: 420.44
• Purity: 99.96%
• Formula: C₁₉H₂₀N₂O₇S
• SMILES: N(C(OC)=O)C=1C=C2C=3C(OC2=CC1)=CC(S(N[C@H](C(C)C)C(O)=O)(=O)=O)=CC3
• Target: MMP
• Solubility: DMSO:50 mg/mL (118.92 mM)

Bioactivity

• In Vivo:
  In mice, MMP-12 Inhibitor (5 mg/kg, p.o.) effectively alleviates rhMMP-12-induced pulmonary inflammatory response by more than 50%.
• In Vitro:
  MMP-12 Inhibitor shows weaker activity against human MMP-3, MMP-13, and MMP-14 with IC50s of 351, 120, and 1100 nM.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MMP-408, MMP-12, MMP-12 Inhibitor, MMP 12, MMP 408

Compound Identifiers

PubChem CID

46245329