Ilomastat (GM-6001)

SKU: orb1305084

Description

Ilomastat (GM6001, Galardin) is a potent broad-spectrum inhibitor of matrix metalloproteinases (MMPs). It is widely used in vitro and in vivo to study MMP roles in cancer, inflammation, and wound healing processes.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 142880-36-2
• MW: 388.46
• Purity: >98%
• Formula: C₂₀H₂₈N₄O₄
• SMILES: CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)CC(=O)NO
• Target: Protease
• Solubility: Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 10 mg/ml).

Bioactivity

• Target IC50:
  MMP3:1.9 nM|MMP8:0.1 nM(Ki)|Eastase:20 nM (Ki)|MMP1:0.4 nM(Ki)|Thermolysin:20 nM (Ki)|MMP26:0.36 nM(Ki)|MMP2:0.5 nM(Ki)|MMP9:0.2 nM(Ki)
• In Vivo:
  Topical application of GM6001 (400 μg/ml) prevents corneal ulceration after severe alkali injury. In rabbit model after stenting, GM6001 significantly inhibits intimal hyperplasia and intimalcollagen content, and it increases lumen area in stented arteries without effects on proliferation rates.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GM-6001

Compound Identifiers

PubChem CID

132519