MMAE-SMCC

SKU: orb1988015

Description

MMAE-SMCC is a conjugation-ready chemical tool combining the potent microtubule inhibitor monomethyl auristatin E (MMAE) with the non-cleavable linker SMCC. This reagent is widely used in research for constructing stable antibody-drug conjugates (ADCs) to evaluate targeted cytotoxicity in both in vitro and in vivo cancer models.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2021179-11-1
• MW: 1140.43
• Purity: 98.08% (May vary between batches)
• Formula: C₅₈H₈₉N₇O₁₄S
• SMILES: [C@H]([C@H](C(N[C@@H]([C@@H](O)C1=CC=CC=C1)C)=O)C)(OC)[C@]2(N(C(C[C@H]([C@@H](N(C([C@@H](NC([C@@H](N(C(CCSC3C(=O)N(CC4CCC(C(ON5C(=O)CCC5=O)=O)CC4)C(=O)C3)=O)C)[C@@H](C)C)=O)C(C)C)=O)C)[C@H](CC)C)OC)=O)CCC2)[H]
• Target: Microtubule Associated,PROTACs,Drug-Linker Conjugates for ADC
• Solubility: DMSO:120 mg/mL (105.22 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (3.51 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DrugLinker Conjugates for ADC, DrugLinkerConjugatesforADC, Auristatin, MMAE SMCC, MMAESMCC, MMAE-SMCC

Compound Identifiers

PubChem CID

146014493