MM927

SKU: orb3173200

Description

MM927 is a potent NVL inhibitor with an IC50 value of 0.053 μM. It disrupts the biosynthesis of the 60S ribosomal subunit within the nucleolus, induces halfmer polysome formation, causes cell cycle arrest at the G1/S and G2/M phases, and triggers apoptosis (apoptosis). Demonstrating antitumor activity in both MOLM-13 acute myeloid leukemia (AML) and HCT116 colorectal cancer (CRC) xenograft models, MM927 can be utilized for studying AML and CRC cancers.

Research Area

Cell Biology

Key Properties

• CAS Number: 3065567-21-4
• MW: 487.51
• Formula: C₂₆H₁₈FN₃O₄S
• SMILES: O=C1OC2=CC=C(C=C2N1C)C(=O)NC3=CC=C4C(SC5=CC(F)=CC=C5C(=O)N4CC#CC)=C3
• Target: Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis