MM-102 TFA

SKU: orb1298648

Description

MM-102 TFA is a potent and selective inhibitor of the WDR5-MLL1 interaction (IC50 = 2.4 nM), disrupting the MLL1 histone methyltransferase complex and reducing H3K4me3 levels. Its application in research, including in vitro studies and somatic cell nuclear transfer models, facilitates the study of epigenetic reprogramming and MLL-fusion driven leukemias.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 1883545-52-5
• MW: 783.83
• Purity: 99.78% (May vary between batches)
• Formula: C₃₇H₅₀F₅N₇O₆
• SMILES: OC(=O)C(F)(F)F.CCC(CC)(NC(=O)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NC1(CCCC1)C(=O)NC(c1ccc(F)cc1)c1ccc(F)cc1
• Target: Histone Methyltransferase
• Solubility: DMSO:99 mg/mL (126.3 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (4.21 mM)

Bioactivity

• Target IC50:
  MLL1:0.4 μM
• In Vitro:
  MM-102, in bone marrow cells transduced with MLL1-AF9 fusion construct shows that the compound effectively decreases the expression of HoxA9 and Meis-1, two critical MLL1 target genes in MLL1 fusion protein mediated leukemogenesis. MM-102 also specifically inhibits cell growth and induces apoptosis in leukemia cells harboring MLL1 fusion proteins.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, HMTase Inhibitor IX, HMTase Inhibitor IX TFA, HistoneMethyltransferase, Histone Methyltransferase, MM 102, MM 102 TFA, MM102, MM-102, MM102 TFA, MM-102 TFA, MLL1, inhibit

Compound Identifiers

PubChem CID

71520620