MLT-748

SKU: orb1706958

Description

MLT-748 is a selective allosteric inhibitor of MALT1, blocking its proteolytic activity. This small molecule is a valuable research tool for studying MALT1-dependent signaling in oncology and immunology, with applications in both in vitro cellular assays and in vivo models of diseases like lymphoma and solid tumors.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 1832578-30-9
• MW: 492.32
• Purity: 99.62% (May vary between batches)
• Formula: C₁₉H₁₉Cl₂N₉O₃
• SMILES: CO[C@H](C)[C@H](OC)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12
• Target: MALT
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (10.16 mM);DMSO:250 mg/mL (507.8 mM)

Bioactivity

• Target IC50:
  MALT1:5 nM|MALT1 (329-728-W580S):13 nM (Kd)|MALT1 (329-728):42 nM (Kd)
• In Vitro:
  In immortalized B cells from MALT1mut/mut patients, MLT-748 (2 µM; 24 hours) increased phosphorylation levels of NF-κB signaling pathway components p65 and IκBα as early as 5 minutes after stimulation with PMA and ionomycin.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MALT1, MALT1329-728, MALT1329-728-W580S, MLT 748, MLT748, MLT-748

Compound Identifiers

PubChem CID

129072285