MLS-544460

SKU: orb1709105

Description

MLS000544460 is a potent, selective, and reversible inhibitor of the Eya2 phosphatase, with a Kd of 2.0 μM and an IC50 of 4 μM. This compound suppresses Eya2-driven cell migration and demonstrates anticancer activity, making it a valuable chemical probe for studying cell signaling and metastasis in cancer research.

Research Area

Cancer Biology, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 352336-36-8
• MW: 341.4
• Purity: >98%
• Formula: C₁₇H₁₂FN₃O₂S
• SMILES: Fc1cccc(c1)C(=O)N\N=C\c1ccc(Sc2ccccn2)o1
• Target: Phosphatase
• Solubility: Soluble in DMSO (40 mg/ml)

Bioactivity

• Target IC50:
  Eya2 phosphatase:(kd)2.0 μM |Eya2 phosphatase:4 μM |Eya2 phosphatase:2.0 μM(kd)|Eya2 phosphatase:4 μM
• In Vitro:
  MLS000544460 binds to Eya2 ED (dialyzed into 10 μM EDTA to remove Mg2+) with a Kd of 0.80 μM. MLS000544460 (10 μM) inhibits Eya2-mediated cell migration in human Eya2, Eya2 phosphatase-dead (D274N), and YFP (as a negative control) expressing MCF10A cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MLS000544460

Compound Identifiers

PubChem CID

7285259