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MLN2480

SKU: orb1223431

Description

TAK-580, also known as MLN2480, BIIB024, and AMG 2112819, is an oral, selective pan-Raf kinase inhibitor. The Raf kinases (A-Raf, B-Raf and C-Raf) are key regulators of cell proliferation and survival within the mitogen-activated protein kinase (MAPK) pathway. The MAPK pathway is frequently disregulated in human cancers, often via activating mutations of Ras or Raf.

Images & Validation

Key Properties

CAS Number1096708-71-2
MW506.29
Purity>98% (HPLC)
FormulaC17H12Cl2F3N7O2S
SMILESNc1ncnc(C(=O)N[C@H](C)c2ncc(C(=O)Nc3ncc(Cl)c(C(F)(F)F)c3)s2)c1Cl
TargetTGFBR
SolubilityDMSO : 50 mg/mL 98.76 mM;

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

TAK-580, TAK 580, TAK580, MLN 2480, MLN-2480, MLN2480

Similar Products

  • TAK-580 [orb1300368]

    99.77% (May vary between batches)

    1096708-71-2

    506.29

    C17H12Cl2F3N7O2S

    2 mg, 50 mg, 100 mg, 5 mg, 10 mg, 1 mg, 1 ml x 10 mM (in DMSO), 25 mg
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Protocol Information

Available Sizes

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200 mg
500 mg
2 mg
$ 130.00
5 mg
$ 180.00
10 mg
$ 310.00
25 mg
$ 510.00
50 mg
$ 740.00
100 mg
$ 1,070.00