MLN2480

SKU: orb1223431

Description

TAK-580, also known as MLN2480, BIIB024, and AMG 2112819, is an oral, selective pan-Raf kinase inhibitor. The Raf kinases (A-Raf, B-Raf and C-Raf) are key regulators of cell proliferation and survival within the mitogen-activated protein kinase (MAPK) pathway. The MAPK pathway is frequently disregulated in human cancers, often via activating mutations of Ras or Raf.

Key Properties

• CAS Number: 1096708-71-2
• MW: 506.29
• Purity: >98% (HPLC)
• Formula: C₁₇H₁₂Cl₂F₃N₇O₂S
• SMILES: Nc1ncnc(C(=O)N[C@H](C)c2ncc(C(=O)Nc3ncc(Cl)c(C(F)(F)F)c3)s2)c1Cl
• Target: TGFBR
• Solubility: DMSO : 50 mg/mL 98.76 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TAK-580, TAK 580, TAK580, MLN 2480, MLN-2480, MLN2480

Quick Database Links

Gene Symbol

TGFBR