ML402

SKU: orb1308026

Description

ML402 (ZINC3671497) is a small molecule activator of the TREK-1 and TREK-2 potassium channels, exhibiting EC50 values of 13.7 μM and 5.9 μM, respectively. This compound is a valuable research tool for investigating the roles of these channels in pain perception, depression, and neuroprotection in both cellular and animal models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 298684-44-3
• MW: 295.78
• Purity: 99.71% (May vary between batches)
• Formula: C₁₄H₁₄ClNO₂S
• SMILES: Cc1cc(Cl)ccc1OCCNC(=O)c1cccs1
• Target: Potassium Channel
• Solubility: DMSO:95 mg/mL (321.18 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (11.16 mM)

Bioactivity

• In Vitro:
  ML402 targets TRAAK with EC50 of 13.6 μM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ML 402, ML402, ML-402, N-[2-(4-chloro-2-methylphenoxy)ethyl]thiophene-2-carboxamide, TREK-2, TREK-1, ZINC3671497, ZINC-3671497, ZINC 3671497, Potassium Channel, PotassiumChannel

Compound Identifiers

PubChem CID

592973