ML349

SKU: orb1308027

Description

ML349 is a potent and selective inhibitor of acyl protein thioesterase 2 (APT2/LYPLA2), exhibiting an IC50 of 144 nM and a Ki of 120 nM. This small molecule is a valuable chemical probe for investigating protein S-depalmitoylation in cellular signaling pathways and related disease models in biochemical and cell-based studies.

Research Area

Metabolism Research

Key Properties

• CAS Number: 890819-86-0
• MW: 454.56
• Purity: 99.88% (May vary between batches)
• Formula: C₂₃H₂₂N₂O₄S₂
• SMILES: COc1ccc(cc1)N1CCN(CC1)C(=O)c1cc2CS(=O)(=O)c3ccccc3-c2s1
• Target: Phospholipase
• Solubility: DMSO:12.5 mg/mL (27.5 mM)

Bioactivity

• Target IC50:
  APT2:(ki)120 nM|LYPLA2:144 nM(ki)
• In Vitro:
  ML349 is an inhibitor of both LYPLA1 and LYPLA2 with IC50s of >3000 and 144 nM, respectively. ML349 also is an inhibitor of acyl protein thioesterase 1 and 2 (APT-1 and APT-2) with Kis of >10000 and 120±20 nM, respectively. ML348 and ML349 do not reduce cell viability, but they cause a slight activation of AKT in NRAS mutant cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Phospholipase, LYPLA2, ML349, ML-349, ML 349, Inhibitor, inhibit, APT-2

Compound Identifiers

PubChem CID

16193817