ML347

SKU: orb1307029

Description

ML347 is a potent and selective small molecule inhibitor of ALK1 and ALK2 kinases, with IC50 values of 46 nM and 32 nM, respectively. It demonstrates over 300-fold selectivity for ALK2 over ALK3. This inhibitor is a valuable research tool for studying BMP signaling in fibrodysplasia ossificans progressiva (FOP) models and other related pathways in both cellular and in vivo contexts.

Research Area

Cardiovascular Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1062368-49-3
• MW: 352.39
• Purity: 98.30% (May vary between batches)
• Formula: C₂₂H₁₆N₄O
• SMILES: COc1ccc(cc1)-c1cnc2c(cnn2c1)-c1cccc2ncccc12
• Target: ALK|||TGF-beta/Smad
• Solubility: DMSO:1 mg/mL (2.84 mM)

Bioactivity

• Target IC50:
  ALK1:46 nM|BMPR1A:10800 nM|ALK2:32 nM
• In Vivo:
  In both human and rat plasma, ML347 exhibits high binding affinity with plasma proteins. Additionally, ML347 demonstrates significant efficacy in C2C12BRA cells responsive to BMP signaling, evidenced by an IC50 value of 15 nM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TGF-β/Smad, TGF-β Receptor, TGFβ, Transforming growth factor beta receptors, Smad, Smad1/5, TGFbeta, TGF-b/Smad, TGFb, TGF-beta, TGFbeta/Smad, ML 347, ML347, ML-347, Inhibitor, inhibit, LDN193719, LDN-193719, LDN 193719, ALK6, ALK1, ALK2, ALK3

Compound Identifiers

PubChem CID

44577753