ML347

SKU: orb1307029

Description

ML347

Research Area

Cardiovascular Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1062368-49-3
• MW: 352.39
• Purity: 99.30%
• Formula: C₂₂H₁₆N₄O
• SMILES: COc1ccc(cc1)-c1cnc2c(cnn2c1)-c1cccc2ncccc12
• Target: TGF-beta/Smad,ALK
• Solubility: DMSO:1 mg/mL (2.84 mM)

Bioactivity

• Target IC50:
  ALK1:46 nM|BMPR1A:10800 nM|ALK2:32 nM
• In Vivo:
  In both human and rat plasma, ML347 exhibits high binding affinity with plasma proteins. Additionally, ML347 demonstrates significant efficacy in C2C12BRA cells responsive to BMP signaling, evidenced by an IC50 value of 15 nM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

TGF-β/Smad, TGF-β Receptor, TGFβ, Transforming growth factor beta receptors, Smad, Smad1/5, TGFbeta, TGF-b/Smad, TGFb, TGF-beta, TGFbeta/Smad, ML 347, ML347, ML-347, Inhibitor, inhibit, LDN193719, LDN-193719, LDN 193719, ALK6, ALK1, ALK2, ALK3

Compound Identifiers

PubChem CID

44577753