ML339

SKU: orb1297919

Description

ML339 is a potent and selective CXCR6 antagonist with an IC50 of 140 nM. It demonstrates high selectivity, showing no activity against CXCR5 or CXCR4. This inhibitor is a valuable research tool for studying CXCR6-mediated functions in inflammation and cancer in both cellular and animal models.

Research Area

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2579689-83-9
• MW: 502
• Purity: 99.90% (May vary between batches)
• Formula: C₂₆H₃₂ClN₃O₅
• SMILES: COc1cc(cc(OC)c1OC)C(=O)N[C@H]1C[C@@H]2CCC[C@H](C1)N2CC(=O)Nc1ccccc1Cl
• Target: CXCR,Arrestin,Apelin receptor
• Solubility: 10% DMSO+90% Corn Oil:4 mg/mL (7.97 mM);DMSO:125 mg/mL (249 mM)

Bioactivity

• Target IC50:
  CXCR6:140 nM
• In Vitro:
  The murine assay was validated using anti-mCXCR16 as an antagonist positive control tested in the presence of an EC80 concentration of mCXCL16 (IC50 = 1.5 nM; % response = 100%). Probe ML339 was shown to be 100-fold less active at the murine CXCR6 receptor using the DiscoveRx β-arrestin cell-based assay format.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

prostate, Inhibitor, ML-339, ML 339, ML339, inhibit, cancer, 2080300-49-6, CXC chemokine receptors, CXCR, CXCR6

Compound Identifiers

PubChem CID

71768224