ML329

SKU: orb1303280

Description

ML329 is a potent small molecule inhibitor that selectively targets the microphthalmia-associated transcription factor (MITF), thereby suppressing its activity on downstream promoters such as TRPM-1. This compound is a valuable research tool for investigating MITF-dependent pathways in melanoma and pigmentation studies, applicable in both in vitro cellular assays and in vivo model systems.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 19992-50-8
• MW: 328.34
• Purity: 99.07% (May vary between batches)
• Formula: C₁₆H₁₂N₂O₄S
• SMILES: NS(=O)(=O)c1ccc(NC2=CC(=O)c3ccccc3C2=O)cc1
• Target: TRP/TRPV Channel
• Solubility: DMSO:10 mg/mL (30.46 mM)

Bioactivity

• Target IC50:
  MITF:1.2 μM.
• In Vitro:
  ML329 effectively reduces the expression of various micropthalmia-associated transcription factor (MITF) target genes and impedes the growth of several cell lines reliant on MITF for proliferation. This compound potentially interacts with MITF or its regulatory elements directly or indirectly. Given MITF's critical role in regulating the cell cycle and pigmentation, ML329's interference with MITF presents a promising approach to elucidate MITF's specific functions in melanoma and to assess the inhibition of MITF's activity as a viable melanoma treatment strategy. Notably, ML329 selectively targets MITF-dependent cells and primary melanocytes without affecting the viability of A375 cells. It also diminishes the expression of key MITF target genes involved in pigmentation and cell cycle regulation, such as CDK2. Thus, ML329 serves as an invaluable research tool to explore MITF's contribution to the development of melanocyte lineage and the progression of melanoma.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TRP Channel, TRPChannel, TRPM-1, TRPV Channel, TRPVChannel, Inhibitor, inhibit, ML329, ML-329, ML 329

Compound Identifiers

PubChem CID

12387471