ML329

SKU: orb1303280

Description

ML329

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 19992-50-8
• MW: 328.34
• Purity: 99.07%
• Formula: C₁₆H₁₂N₂O₄S
• SMILES: NS(=O)(=O)c1ccc(NC2=CC(=O)c3ccccc3C2=O)cc1
• Target: TRP/TRPV Channel,Others
• Solubility: DMSO:10 mg/mL (30.46 mM)

Bioactivity

• Target IC50:
  MITF:1.2 μM.
• In Vitro:
  ML329 effectively reduce the expression of various micropthalmia-associated transcription factor (MITF) target genes and impede the growth of several cell lines reliant on MITF for proliferation. This compound potentially interacts with MITF or its regulatory elements directly or indirectly. Given MITF's critical role in regulatin the cell cycle and pigmentation, ML329's interference with MITF presents a promising approach to elucidate MITF's specific functions in melanoma and to asses the Inhibition of MITF's activity as a viable melanoma treatment strategy. Notably, ML329 selectively targets MITF-dependent cells and Primary melanocytes without affectin the viability of A375 cells. It also diminishe the expression of key MITF target genes involved in pigmentation and cell cycle regulation, such as CDK2. Thus, ML329 serves as an invaluable research tool to explore MITF's contribution to the development of melanocyte lineage an the progression of melanoma.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

TRP Channel, TRPChannel, TRPM-1, TRPV Channel, TRPVChannel, Inhibitor, inhibit, ML329, ML-329, ML 329

Compound Identifiers

PubChem CID

12387471