ML324

SKU: orb1300631

Description

ML324

Research Area

Epigenetics & Chromatin, Infectious Disease & Virology

Key Properties

• CAS Number: 1222800-79-4
• MW: 349.43
• Purity: 98.57%
• Formula: C₂₁H₂₃N₃O₂
• SMILES: CN(C)CCCNC(=O)c1ccc(cc1)-c1cc(O)c2ncccc2c1
• Target: Virus Protease,HSV,Histone Demethylase
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:40 mg/mL (114.47 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.72 mM);Ethanol:3 mg/mL (8.59 mM)

Bioactivity

• Target IC50:
  JMJD2:920 nM
• In Vivo:
  In a mouse ganglia explant model of latently infected mice, ML324 suppresses the formation of HSV plaques, and blocks HSV-1 reactivation.
• In Vitro:
  ML324 exhibits good Caco-2 cell permeability, and possesses excellent microsomal stability in the presence of both mouse and rat liver microsomes. ML324 demonstrates potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection by inhibiting viral IE gene expression.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cytomegalovirus, domain, disease, containing, CMV, ML324, ML-324, ML 324, Jumonji, immunity, inflammation, JMJD2, inhibit, Herpes simplex virus, herpes, human, HSV, Inhibitor, Histone Demethylase, HistoneDemethylase, H3K9, proteins, periodontal, periodontitis, simplex, virus

Compound Identifiers

PubChem CID

44143209