ML311

SKU: orb1302084

Description

ML311 is a small molecule that selectively disrupts the Mcl-1/Bim protein-protein interaction. This inhibitor is utilized in cancer research to study apoptosis and has been employed in both in vitro cellular assays and in vivo xenograft models to investigate Mcl-1-dependent tumor survival.

Research Area

Cell Biology

Key Properties

• CAS Number: 315698-17-0
• MW: 415.45
• Purity: 99.75%
• Formula: C₂₃H₂₄F₃N₃O
• SMILES: CCN1CCN(CC1)C(c1ccc(cc1)C(F)(F)F)c1ccc2cccnc2c1O
• Target: Bcl-2 Family
• Solubility: DMSO:50 mg/mL (120.35 mM);H2O:Insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.81 mM);Ethanol:20 mg/mL (48.14 mM)

Bioactivity

• In Vitro:
  ML311 potently halts the viability of several Mcl-1 primed cells, including MCL-1-1780 (EC50: 0.31 μM), NCI-H929 (EC50: 1.6 μM), and DHL-6 (EC50: 3.3 μM), with a high maximal effect (>80%). Additionally, ML311 displays activity in a leukemia-derived cell line reliant on Bcl-2 function (Bcl2-1863, EC50: 1.1 μM). ML311 exhibits strong growth inhibitory effects in numerous cell lines, with GI50<900 nM for nine cell types (RPMI-8226, SR, NCI-H322M, NCI-H60, HCC-2998, KM12, SF-295, U251, PC-3), and <2 μM for 14 additional types.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bcl-2 Family, ML311, ML-311, ML 311, Inhibitor, inhibit, Mcl-1

Compound Identifiers

PubChem CID

3384730