ML281

SKU: orb1304214

Description

ML281 is a highly selective small molecule inhibitor of STK33, demonstrating potent activity with an IC50 of 14 nM. It is a valuable research tool for studying STK33 function in cancer biology and has been utilized in both in vitro cellular assays and in vivo xenograft models to investigate oncogenic signaling pathways.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 1404437-62-2
• MW: 389.47
• Purity: 99.87% (May vary between batches)
• Formula: C₂₂H₁₉N₃O₂S
• SMILES: CC(C)c1ccc(NC(=O)c2cccs2)c(c1)-c1nc2ccccc2[nH]c1=O
• Target: Serine Protease
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:50 mg/mL (128.38 mM)

Bioactivity

• Target IC50:
  STK33:14 nM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, ML 281, ML281, ML-281, inhibit, SerineProtease, Serine Protease, STK33

Compound Identifiers

PubChem CID

53377448