ML240

SKU: orb1304103

Description

ML240 is a potent and selective small molecule inhibitor that targets the AAA+ ATPase p97 (VCP) by competitively binding to its ATPase sites. It is widely used in cancer and neurodegenerative disease research to probe p97 function in protein homeostasis, with applications in both cellular and in vivo models.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 1346527-98-7
• MW: 396.44
• Purity: 99.66%
• Formula: C₂₃H₂₀N₆O
• SMILES: COc1cccc2c(NCc3ccccc3)nc(nc12)-n1c(N)nc2ccccc12
• Target: p97
• Solubility: DMSO:50 mg/mL (126.12 mM);10% DMSO+90% Corn Oil:2.5 mg/mL (6.31 mM)

Bioactivity

• Target IC50:
  p97:100 nM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

VCP, Cdc48, p97, P97, inhibit, ML240, ML-240, ML 240, Inhibitor

Compound Identifiers

PubChem CID

49830258