ML224

SKU: orb1706965

Description

ML224

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1338824-21-7
• MW: 525.59
• Purity: 99.14%
• Formula: C₃₁H₃₁N₃O₅
• SMILES: COc1ccc(cc1COc1c(C)cc(NC(C)=O)cc1C)C1Nc2ccccc2C(=O)N1Cc1ccco1
• Target: TSH Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.28 mM);DMSO:80 mg/mL (152.21 mM)

Bioactivity

• Target IC50:
  HEK293 cells:2.1 μM|LHR:＞30 μM|TSHR:2.1 μM|FSHR:＞30 μM
• In Vivo:
  ML224(ANTAG3) 2 mg per mouse; administered through intraperitoneal infusion pump; once daily for 3 days) reduces serum FT4 levels and thyroid mRNA of TPO and NIS in mice subjected to prolonged TRH stimulatio.
• In Vitro:
  In human embryonic kidney 293 cells, ML224 exhibits a half-maximal inhibitory concentration IC50 of 2.1 μM against TSHR after a 20-minute exposure, with a range of 0.001-100 μM the half-maximal inhibitory concentration against LH and FSH receptors exceed 30 μ.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

ANTAG 3, ANTAG3, ANTAG-3, ML224, ML-224, ML 224, NCGC 00242364, NCGC00242364, NCGC-00242364, thyrotropin receptor (TSHR), TSH Receptor, TSHReceptor

Compound Identifiers

PubChem CID

50897809