ML188

SKU: orb1298991

Description

ML188 is a selective, noncovalent inhibitor of the SARS-CoV 3CL protease (IC50 = 1.5 µM). This moderate molecular weight compound demonstrates good inhibitory activity in enzymatic and antiviral cell-based assays, making it a useful chemical probe for coronavirus research.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 1417700-13-0
• MW: 433.54
• Purity: 99.69% (May vary between batches)
• Formula: C₂₆H₃₁N₃O₃
• SMILES: CC(C)(C)NC(=O)[C@H](N(C(=O)c1ccco1)c1ccc(cc1)C(C)(C)C)c1cccnc1
• Target: Virus Protease,SARS-CoV
• Solubility: DMSO: 4.34 mg/mL (10.01 mM), sonication is recommended.

Bioactivity

• Target IC50:
  3CLpro (SARS CoV):1.5 μM
• In Vitro:
  Probe 16-(R) (ML188) is a modest molecular weight SARS-CoV 3CLpro inhibitor with demonstrated antiviral activity and a non-covalent mechanism of action.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

antiviral, infection, Inhibitor, inhibit, non-covalent, ML 188, ML188, ML-188, SARS-CoV, SARS coronavirus, SARSCoV, replication, probe, Virus Protease, VirusProtease

Compound Identifiers

PubChem CID

46897844