ML179

SKU: orb1685339

Description

ML179 is a potent and selective inverse agonist targeting the nuclear receptor LRH-1 (NR5A2), exhibiting an IC50 of 320 nM. This small molecule is a valuable research tool for investigating LRH-1's role in metabolic regulation, stem cell biology, and cancer, facilitating both in vitro mechanistic studies and in vivo model research.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1883548-87-5
• MW: 422.44
• Purity: 99.77% (May vary between batches)
• Formula: C₂₁H₂₅F₃N₄O₂
• SMILES: FC(F)(F)c1cccc(c1)N1CCN(CC1)c1cc(=O)n(C2CCCCC2)c(=O)[nH]1
• Target: Orphan Receptor,Others
• Solubility: DMSO:4.25 mg/mL (10.06 mM)

Bioactivity

• Target IC50:
  LRH1, NR5A2 (liver receptor homolog-1):320 nM

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, inverse, liver receptor homolog-1 (LRH1, NR5A2), ML179, ML-179, ML 179, ER-negative breast cancer, MCF-7, Inhibitor, C57Bl6 mice, SAA4, SAA1, probe compounds

Compound Identifiers

PubChem CID

45100448