ML167

SKU: orb1305187

Description

ML167 (CID44968231) is a potent and selective small molecule inhibitor of Cdc2-like kinase 4 (Clk4). This compound is a valuable research tool for studying Clk4 function in splicing regulation and has been utilized in both cellular and biochemical assays to investigate kinase signaling pathways.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1285702-20-6
• MW: 335.36
• Purity: >99.99% (May vary between batches)
• Formula: C₁₉H₁₇N₃O₃
• SMILES: Cc1ccc(CNc2ncnc3ccc(cc23)-c2ccc(CO)o2)o1
• Target: CDK,DYRK
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:11 mg/mL (32.8 mM);DMSO:62 mg/mL (184.88 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.98 mM)

Bioactivity

• Target IC50:
  CLK4:136 nM|CLK2:1648 nM|DYRK1A:＞10000 nM|DYRK1B:4420 nM|CLK1:1522 nM|CDK3:＞10000 nM
• In Vivo:
  ML167 exhibits high cellular permeability and serves as a probe for Clk4 in Caco-2 assays.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CLK4, CLK1, CLK2, cell permeability, CDK, CID44968231, CID-44968231, CID 44968231, Cyclin dependent kinase, Dyrk1B, Caco-2 cells, furan ring, Inhibitor, inhibit, NCGC00188654, NCGC-00188654, NCGC 00188654, ML 167, ML167, ML-167

Compound Identifiers

PubChem CID

44968231