ML141

SKU: orb1224170

Description

ML141 is a potent, selective and reversible non-competitive inhibitor of Rho family GTPase cdc42 with IC50 of 200 nM.

Key Properties

• CAS Number: 71203-35-5
• MW: 407.49
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₁N₃O₃S
• SMILES: O=S(C1=CC=C(N2N=C(C3=CC=CC=C3)CC2C4=CC=C(OC)C=C4)C=C1)(N)=O
• Target: CDK
• Solubility: DMSO: 81 mg/mL warmed (198.77 mM)

Bioactivity

• In Vivo:
  ML141 (CID-2950007) (10 μM; intracerebroventricular injection) causes acute anxiety in mice. Animal model: C57Bl/6J mice. Dosage: 10 μM. Administration: Intracerebroventricular injection. Result: Increased anxiety in mice.
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• In Vitro:
  ML141 (CID-2950007) is not cytotoxic in either cell line at doses of 0.1-3 μM after treatment for 4 days. OVCA429 cells were insensitive to 10 μM compound, whereas some cytotoxicity was observed in SKOV3ip cells at this concentration after a 4-day treatment, although it did not reach statistical significance. ML141 is not cytotoxic toward Swiss 3T3 or Vero E6 cells up to 10 μM for 24 and 48 h, respectively. ML141 inhibits 3T3 fibroblast filopodia formation and inhibits ovarian cancer cell migration.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CID2950007

Quick Database Links

Gene Symbol

CDK