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ML SA1

SKU: orb1218154

Description

ML-SA1 is a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively.

Images & Validation

Key Properties

CAS Number332382-54-4
MW362.42
Purity>98% (HPLC)
FormulaC22H22N2O3
SMILESCC(CC1(C)C)c(cccc2)c2N1C(CN(C(c1c2cccc1)=O)C2=O)=O
TargetTRPML
SolubilityDMSO:17 mg/mL (46.90 mM)

Bioactivity

In Vitro
Western blot analysis. Cell line: A549 cells. Concentration: 25 μM. Incubation time: 0~14 hours. Result: Possibly affected the entry of DENV2 into host cells.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Mucolipin synthetic agonist 1

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ML SA1 (orb1218154)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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Available Sizes

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500 mg
5 mg
$ 90.00
10 mg
$ 130.00
25 mg
$ 230.00
50 mg
$ 360.00
100 mg
$ 520.00
200 mg
$ 770.00