ML-9

SKU: orb1308028

Description

ML-9 is a cell-permeable inhibitor of Akt, MLCK, and STIM1, with respective Ki values of 4, 32, and 54 μM. It is widely used in research to study autophagy, calcium signaling, and cytoskeletal dynamics in both cellular and animal models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 105637-50-1
• MW: 361.29
• Purity: 99.69% (May vary between batches)
• Formula: C₁₅H₁₈Cl₂N₂O₂S
• SMILES: Cl.Clc1cccc2c(cccc12)S(=O)(=O)N1CCCNCC1
• Target: Myosin,Akt,Calcium Channel
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.54 mM);DMSO:25 mg/mL (69.2 mM)

Bioactivity

• In Vitro:
  ML9 (50 μM; 1-4 hours) obviously enhances cleaved caspase-3 levels, reduced STIM1 protein levels by about 42%. ML9 (0-100 μM; 0-24 hours) has no reduction in cardiomyocyte viability, 50-100 μM obviously causes cell death .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CalciumChannel, Calcium Channel, cardiomyocyte, caspase, AKT, ML 9, ML9, ML-9, MLCK, inhibit, Inhibitor, Myosin, viability, STIM1

Compound Identifiers

PubChem CID

108047