ML-297

SKU: orb1302671

Description

ML 297 is a potent and selective activator of GIRK1/2 (Kir3.1/3.2) channels, demonstrating high selectivity over related GIRK subtypes and other ion channels. This small molecule is a valuable research tool for investigating GIRK channel function in neurological and cardiovascular research, with applications in both in vitro and in vivo experimental models.

Research Area

Neuroscience

Key Properties

• CAS Number: 1443246-62-5
• MW: 328.32
• Purity: >98%
• Formula: C₁₇H₁₄F₂N₄O
• SMILES: Cc1cc(NC(=O)Nc2ccc(F)c(F)c2)n(n1)-c1ccccc1
• Target: Ion channel
• Solubility: Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 20 mg/ml).

Bioactivity

• Target IC50:
  GIRK1/4:887nM|GIRK1/3:914 nM|GIRK1/2:160nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

VU0456810

Compound Identifiers

PubChem CID

56642816