ML 297

SKU: orb1302671

Description

ML 297 is a potent and selective activator of GIRK1/2 (Kir3.1/3.2) channels, demonstrating high selectivity over related GIRK subtypes and other ion channels. This small molecule is a valuable research tool for investigating GIRK channel function in neurological and cardiovascular research, with applications in both in vitro and in vivo experimental models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1443246-62-5
• MW: 328.32
• Purity: 97.85% (May vary between batches)
• Formula: C₁₇H₁₄F₂N₄O
• SMILES: Cc1cc(NC(=O)Nc2ccc(F)c(F)c2)n(n1)-c1ccccc1
• Target: Potassium Channel
• Solubility: DMSO:45 mg/mL (137.06 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.09 mM)

Bioactivity

• Target IC50:
  GIRK1/4:887nM|GIRK1/3:914 nM|GIRK1/2:160nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

convulsions, CID 56642816, CID56642816, CID-56642816, Inhibitor, epilepsy, GIRK, GIRK1/2, inhibit, KcsA, Kir3.1/3.2 (GIRK1/2) channel, ML 297, ML297, ML-297, Potassium Channel, PotassiumChannel, VU 0456810, VU0456810, VU-0456810

Compound Identifiers

PubChem CID

56642816