ML210

SKU: orb1298988

Description

ML-210 is a potent, selective, and covalent GPX4 inhibitor (EC50=30 nM). It is a research tool used to induce ferroptosis, a form of regulated cell death, and has demonstrated antitumor activity in both cellular and in vivo cancer models.

Research Area

Cell Biology

Key Properties

• CAS Number: 1360705-96-9
• MW: 475.3
• Purity: >98%
• Formula: C₂₂H₂₀Cl₂N₄O₄
• SMILES: Cc1onc(C(=O)N2CCN(CC2)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1[N+]([O-])=O
• Target: Glutathione
• Solubility: Soluble in DMSO (up to 30 mg/ml)

Bioactivity

• Target IC50:
  GPX4:30 nM(EC50)
• In Vitro:
  METHODS: Human lung adenocarcinoma cell line HCC4006 was treated with ML-210 (10 µM) for 1 h. CETSA profiles were detected by Western Blot. RESULTS: ML-210 affects the thermal stability of GPX4, consistent with the binding to the cellular target. METHODS: DRD cell lines were treated with ML-210 for 48 h, and cell viability was measured. RESULTS: ML-210 has an IC50 of 107 nM in the DRD cell line.
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Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Covalent, CID 49766530, CID49766530, CID-49766530, anti-cancer, inhibit, ML210, ML-210, ML 210, Inhibitor, Ferroptosis, GlutathionePeroxidase, GPX4, Gpx4, glutathione, Glutathione Peroxidase, Ras, peroxidase, selenocysteine, residue

Compound Identifiers

PubChem CID

49766530