ML-180

SKU: orb1309410

Description

ML-180 (SR1848) is a potent small molecule inverse agonist of the orphan nuclear receptor LRH-1 (NR5A2), exhibiting an IC50 of 3.7 µM. This compound is a valuable research tool for studying LRH-1's role in metabolism, inflammation, and cancer in both cellular and animal models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 863588-32-3
• MW: 388.89
• Purity: 99.74%
• Formula: C₂₀H₂₅ClN₄O₂
• SMILES: Clc1cccc(c1)N1CCN(CC1)c1cc(=O)n(C2CCCCC2)c(=O)[nH]1
• Target: Orphan Receptor,Others
• Solubility: DMSO:11 mg/mL (28.29 mM)

Bioactivity

• Target IC50:
  LRH1:3.7 µM (IC50)
• In Vivo:
  ML-180 has a statistically significant decrease of both LRH-1 and SHP mRNA in adrenal glands and pancreatic tissue.
• In Vitro:
  ML-180 (0.5-5 μM; 24 hours) shows a significant inhibition of cyclin-D1 and cyclin-E1 expression in hepatic cells, but has little effect on repression in SK-OV-3 cells. ML-180 (5 μM; 24 hours) leads to a rapid decrease of LRH-1 expression and efficiently represses endogenous LRH-1 signaling.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cancers, factor-1, Inhibitor, homolog, inhibit, NR5A2, NR5A1, liver, nuclear, Orphan, orphan nuclear receptor NR5A2, LRH-1, ML180, ML-180, ML 180, SF-1, receptor, SR1848, SR-1848, SR 1848, steroidogenic

Compound Identifiers

PubChem CID

3238389