ML-148

SKU: orb1303711

Description

ML-148 is a potent and selective inhibitor of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) with an IC50 of 56 nM. This compound is a valuable chemical probe for studying prostaglandin signaling pathways in vitro and has been utilized in research exploring tissue regeneration and hematopoietic recovery in vivo.

Research Area

Metabolism Research

Key Properties

• CAS Number: 451496-96-1
• MW: 319.4
• Purity: 99.88% (May vary between batches)
• Formula: C₂₀H₂₁N₃O
• SMILES: Cc1cccc(c1)-n1cnc2cc(ccc12)C(=O)N1CCCCC1
• Target: Dehydrogenase
• Solubility: DMSO:11 mg/mL (34.44 mM);DMF:PBS(pH 7.2)(1:1):0.5 mg/mL (1.57 mM);DMF:25 mg/mL (78.27 mM);Ethanol:10 mg/mL (31.31 mM)

Bioactivity

• In Vitro:
  ML148 (10 nM) reduces the apparent Km by half and decreases Vmax by 25%. ML148 shows selectivity with IC50s of 36000, >57500, >57500 nM for ALDH1A1, HADH2, HSD17β4, respectively.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PGE2, selective, prostaglandin-signaling, Inhibitor, inhibit, ML 148, ML148, ML-148, NAD+, 15-PGDH, 15-Hydroxyprostaglandin dehydrogenase

Compound Identifiers

PubChem CID

3243760