ML 10302 hydrochloride

SKU: orb1704363

Description

ML 10302 hydrochloride is a selective 5-HT4 receptor agonist, exhibiting high affinity (Ki = 1.07 nM) for 5-HT4 and lower affinity (Ki = 782 nM) for 5-HT3 receptors. This small molecule is a valuable research tool for investigating serotonin signaling in gastrointestinal, neurological, and cardiac systems in both in vitro and in vivo models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 186826-17-5
• MW: 349.25
• Purity: 99.99% (May vary between batches)
• Formula: C₁₅H₂₂Cl₂N₂O₃
• SMILES: COC1=CC(=C(C=C1C(=O)OCCN2CCCCC2)Cl)N.Cl
• Target: 5-HT Receptor
• Solubility: Ethanol:< 6.99 mg/mL;DMSO:12 mg/mL (34.36 mM)

Bioactivity

• Target IC50:
  5-HT4 receptor:1.07 nM (Ki)|5-HT4 receptor:4 nM (EC50)|5-HT3 receptor:782 nM (Ki)
• In Vivo:
  In male C57BL/6j wild-type mice, subcutaneous injection of ML 10302 hydrochloride (5, 10 and 20 mg/kg) increases the production of soluble form of amyloid precursor protein.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ML 10302 Hydrochloride, ML 10302 hydrochloride, ML10302 Hydrochloride, ML-10302 Hydrochloride, 5HTReceptor, 5HT Receptor, 5-HT4

Compound Identifiers

PubChem CID

56972230