ML-099

SKU: orb1305755

Description

ML-099 is a broad-spectrum small molecule activator of Ras-related GTPases, including Rac1, Ras, Rab7, Rab2A, and Cdc42. It serves as a valuable research tool for investigating GTPase signaling pathways in both cellular and biochemical assays, with applications in cell biology, neuroscience, and cancer research.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 496775-95-2
• MW: 259.32
• Purity: 99.73% (May vary between batches)
• Formula: C₁₄H₁₃NO₂S
• SMILES: OC(=O)c1cccnc1SCCc1ccccc1
• Target: Rho,Ras
• Solubility: DMSO:50 mg/mL (192.81 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.71 mM)

Bioactivity

• Target IC50:
  Ras:95.5 nM(activated mutant,EC50)|Cell division cycle 42:100 nM(wild type,EC50)|Cell division cycle 42:58.88 nM(activated mutant,EC50)|Rac1:20.17 nM(wild type,EC50)|Rac1:25.42 nM(activated mutant,EC50)
• In Vitro:
  ML-099 activates Ras protein wild type(EC50 = 141.25 nM), Rab7(EC50 = 181.97 nM), Rab-2A(EC50 = 354.81 nM), Rac1 protein activated mutant(EC50 = 25.42 nM), Rac1 protein wild type(EC50 = 20.17 nM), Ras protein activated mutant(EC50 = 95.5 nM), cell division cycle 42 activated mutant(EC50 = 58.88 nM) and cell division cycle 42 wild type(EC50 = 100 nM).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Rab2A, Rab7, Rac1, Ras, inhibit, ML099, ML-099, ML 099, Inhibitor, ab-2A, CID888706, CID-888706, CID 888706, cell division cycle 42

Compound Identifiers

PubChem CID

888706