ML-090

SKU: orb1305756

Description

ML-090 is a potent and selective small molecule inhibitor of NADPH oxidase 1 (NOX1), exhibiting an IC50 of 90 nM. It demonstrates >100-fold selectivity over NOX2, NOX3, and NOX4 isoforms (IC50 >10 µM). This inhibitor is a valuable research tool for studying NOX1's role in cellular redox signaling, inflammation, and cancer progression in both in vitro and in vivo models.

Research Area

Immunology & Inflammation, Metabolism Research

Key Properties

• CAS Number: 531-46-4
• MW: 234.26
• Purity: 98.55% (May vary between batches)
• Formula: C₁₄H₁₀N₄
• SMILES: N1c2ccccc2Nc2nc3ccccc3nc12
• Target: NADPH,NADPH-oxidase
• Solubility: DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vitro:
  In HEK293 cells, ML-090 has an IC50 of 360 nM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ML090, ML-090, ML 090, NADPHoxidase, NADPH Oxidase, NOX, NOX1, NOX2, NOX3, NOX4, inhibit, Inhibitor, Fluoflavine, HEK293 cell

Compound Identifiers

PubChem CID

616479