MKI-3

SKU: orb3210892

Description

MKI-3 is a selective inhibitor of microtubule-associated serine/threonine-like kinase (MASTL), with an IC50 of 5.72 nM and a Kd of 1.89 nM. It disrupts the MASTL-ENSA-Aurora A signaling axis. Additionally, MKI-3 induces chromosomal instability, mitotic catastrophe, and apoptosis in cancer cells, and can be utilized in research related to triple-negative breast cancer.

Key Properties

• CAS Number: 3084702-28-0
• MW: 385.42
• Formula: C₂₁H₁₉N₇O
• SMILES: O=C(N)C1=CC=C(C=C1)NC=2N=C3C=CC=CC3=C(N2)NC4=NNC(=C4)C5CC5
• Target: Apoptosis,Caspase,Aurora Kinase,PARP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,Caspase,Aurora Kinase,PARP