MKI-2

SKU: orb3209960

Description

MKI-2 is a selective MASTL inhibitor with an IC50 of 37.44 nM. MKI-2 induces mitotic catastrophe through modulation of the MASTL–PP2A axis in breast cancer cells. MKI-2 reduces phospho-ENSA, total and phospho-c-Myc levels. MKI-2 inhibits cancer cell proliferation, migration, and induces DNA damage, and also inhibits germinal vesicle breakdown in mouse oocytes. MKI-2 is utilized in biomedical research focused on cell-cycle regulation, mitotic checkpoint control, and MASTL-dependent signaling networks in cancer-associated biological systems.

Key Properties

• CAS Number: 438204-56-9
• MW: 381.43
• Purity: 99.99% (May vary between batches)
• Formula: C₂₂H₁₉N₇
• SMILES: N#CCC1=CC=C(C=C1)NC=2N=C3C=CC=CC3=C(N2)NC4=NNC(=C4)C5CC5
• Target: Serine/threonin kinase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Serine/threonin kinase