MK2-IN-1 hydrochloride

SKU: orb1302856

Description

MK2-IN-1 hydrochloride is a potent and selective allosteric inhibitor of MAPKAPK2 (MK2), exhibiting an IC50 of 0.11 µM. This compound is a valuable research tool for studying p38 MAPK signaling in inflammatory processes and has been utilized in both cellular and animal models of inflammation and autoimmune diseases.

Research Area

Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 1314118-94-9
• MW: 509.43
• Purity: 99.67%
• Formula: C₂₇H₂₆Cl₂N₄O₂
• SMILES: Cl.Clc1ccc(cc1)-c1ccc(o1)C(=O)N(Cc1ccccn1)c1ccc(cc1)N1CCNCC1
• Target: MAPK,HSP
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.96 mM);DMSO:50 mg/mL (98.15 mM);H2O:Insoluble

Bioactivity

• Target IC50:
  MK2:0.11 Μm
• In Vitro:
  MK2-IN-1 has been shown to inhibit pro-inflammatory cytokine secretion from the human THP-1 acute monocytic leukemia cell line, causing inhibition of LPS-stimulated TNF-α (IC50: 4.4 μM) and IL-6 (IC50: 5.2 μM) secretion.1 It can also inhibit IL-1β-stimulated matrix-metalloprotease 13 secretion from the SW1353 chondrosarcoma cell line (IC50: 5.7 μM) and human primary chondrocyte cultures (IC50: 2.2 μM) .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, MAP kinase activated protein kinase 2, MAPK activated protein kinase 2, MAPKAPK2 (MK2), MAPKAP kinase 2, inhibit, Mitogen-activated protein kinase activated protein kinase 2, MK 25, MK2, MK25, MK-25, MK2IN1 hydrochloride, MK-2-IN-1 hydrochloride, MK2-IN-1 Hydrochloride, MK2 IN 1 hydrochloride, MK2 Inhibitor

Compound Identifiers

PubChem CID

70681199