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MK 8776

SKU: orb1223735

Description

MK 8776 (SCH 900776) is a potent and functionally selective CHK1 inhibitor (IC50=3 nM) with minimal intrinsic antagonistic properties; also inhibits CDK2 with IC50 of 160 nM, weak activity for CHK2 and no significant inhibition of cytochrome P450 isoforms; induces dose-dependent suppression of CHK1 pS296 and concomitant accumulation of phospho-RPA signal in U2OS cells; interacts synergistically with DNA antimetabolite agents in vitro and in vivo to selectively induce dsDNA breaks and cell death in the A2780 xenograft model.Blood Cancer Phase 2 Discontinued.

Images & Validation

Key Properties

CAS Number891494-63-6
MW376.25
Purity>98% (HPLC)
FormulaC15H18BrN7
SMILESNC1=C(Br)C([C@H]2CNCCC2)=NC3=C(C4=CN(C)N=C4)C=NN13
TargetChk
SolubilityDMSO: 3 mg/mL (7.97 mM); Ethanol: <1 mg/mL; Water: <1 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

SCH 900776

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Protocol Information

Available Sizes

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200 mg
500 mg
2 mg
$ 130.00
5 mg
$ 200.00
10 mg
$ 280.00
25 mg
$ 470.00
50 mg
$ 760.00
100 mg
$ 1,080.00