MK-8325

SKU: orb1703076

Description

MK-8325 is an orally bioavailable small molecule inhibitor targeting the HCV NS5A protein, exhibiting potent activity across multiple genotypes. It demonstrates favorable pharmacokinetic properties in both cellular and animal studies, supporting its use in antiviral research and hepatitis C drug development.

Research Area

Infectious Disease & Virology, Protein Biochemistry

Key Properties

• CAS Number: 1334314-19-0
• MW: 915.93
• Purity: >99.99% (May vary between batches)
• Formula: C₄₃H₅₄Cl₂F₂N₈O₆Si
• SMILES: COC(N[C@@H](C(C)C)C(N1[C@@H](C[Si](C)(C1)C)C2=NC3=C(C4=CC=C(C5=CC=C(C6=CN=C([C@H]7N(CC(F)(C7)F)C([C@H](C(C)C)NC(OC)=O)=O)N6)C=C5)C=C4C=C3)N2)=O)=O.Cl.Cl
• Target: HCV Protease
• Solubility: DMSO:9.16 mg/mL (10 mM)

Bioactivity

• In Vivo:
  In vivo assays showed MK-8325 to be orally bioavailable with pharmacokinetics suitable for once-daily dosing in patients and good overall ADME profiles.
  Read more...
• In Vitro:
  MK-8325 (7 μM) demonstrates no cell toxicity with a CC50 > 25 mM against Huh-7 replicon cells in a standard MTS assay.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MK8325, MK-8325, MK 8325, HCVProtease, HCV NS5A, HCV Protease

Compound Identifiers

PubChem CID

126480214