MK-6892

SKU: orb1296197

Description

MK-6892

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 917910-45-3
• MW: 386.4
• Purity: 99.01%
• Formula: C₁₉H₂₂N₄O₅
• SMILES: CC(C)(Cc1nc(no1)-c1ccc(O)cn1)C(=O)NC1=C(CCCC1)C(O)=O
• Target: GPCR
• Solubility: DMSO:45 mg/mL (116.46 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.18 mM)

Bioactivity

• Target IC50:
  GPR109A:4 nM (Ki)|GPR109A:16 nM (EC50)
• In Vivo:
  MK-6892 is administered orally to WT and nicotinic acid (NA) receptor null mice on a C57Bl/6 genetic background. Following a 100 mg/kg dose, blood levels of MK-6892 reach 229 μM in WT mice and 148 μM in NA receptor null mice after 15 minutes, significantly exceeding the in vitro EC50 (240 nM). MK-6892 effectively suppresses plasma FFA in WT mice, but not in NA receptor null mice, indicating NA receptor-dependent FFA reduction .
• In Vitro:
  MK-6892 effectively induces the internalization of GPR109A in U2OS β-arrestin2-RrGFP cells and demonstrates a potent EC50 of 74 nM in calcium mobilization assays .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MK 6892, MK6892, MK-6892, inhibit, Inhibitor, HCAR2, HCA2, HM74A, GPR109A, PUMA-G

Compound Identifiers

PubChem CID

135416394