MK-5046

SKU: orb1705166

Description

MK-5046 is a potent and selective bombesin receptor subtype-3 (BRS-3) agonist, exhibiting high binding affinity for both mouse (Ki=1.6 nM) and human (Ki=25 nM) receptors. This small molecule is a valuable research tool for investigating BRS-3 function in metabolic regulation and energy homeostasis through in vitro and in vivo studies.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1022152-70-0
• MW: 444.37
• Purity: 99.91% (May vary between batches)
• Formula: C₂₀H₁₈F₆N₄O
• SMILES: O[C@@](Cc1nc(CC2(CC2)C(F)(F)F)c[nH]1)(c1ccc(cc1)-n1cccn1)C(F)(F)F
• Target: Bombesin Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.25 mM);DMSO:10 mM

Bioactivity

• Target IC50:
  BRS3 (human):25 nM(ki)|BRS3 (mouse):1.6 nM (ki)

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BombesinReceptor, Bombesin Receptor, BRS-3, inhibit, MK5046, MK-5046, MK 5046, Inhibitor

Compound Identifiers

PubChem CID

49871766