MK-4827 Racemate

SKU: orb1305758

Description

MK-4827 Racemate (Niraparib Racemate) is a potent and selective inhibitor of PARP1 and PARP2, exhibiting IC50 values of 3.8 nM and 2.1 nM, respectively. It shows over 330-fold selectivity against PARP3, V-PARP, and Tank1. This compound is widely used in cancer research, particularly for studying DNA damage response and synthetic lethality in both cellular and animal models of BRCA-mutant cancers.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1038915-75-1
• MW: 320.39
• Purity: 99.86% (May vary between batches)
• Formula: C₁₉H₂₀N₄O
• SMILES: NC(=O)c1cccc2cn(nc12)-c1ccc(cc1)C1CCCNC1
• Target: PARP
• Solubility: DMSO:60 mg/mL (187.27 mM)

Bioactivity

• Target IC50:
  PARP2:2.1 nM|PARP1:3.8 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Niraparib Racemate, MK4827 Racemate, MK-4827 Racemate, PARP1, PARP2, MK 4827 Racemate, 2-(4-piperidin-3-ylphenyl)indazole-7-carboxamide

Compound Identifiers

PubChem CID

24958198