MK-4827 hydrochloride

SKU: orb1227084

Description

A highly potent PARP inhibitor with IC50 of 3.8 nM/2.1 nM for PARP1/PARP2; inhibits PARP activity with EC50=4 nM in a whole cell assay, and inhibits proliferation of cancer cells with mutant BRCA-1 and BRCA-2 with CC50 in the 10 100 nM range; well tolerated in vivo and demonstrates efficacy as a single agent in a xenograft model of BRCA-1 deficient cancer.Ovarian Cancer Approved.

Key Properties

• CAS Number: 1038915-64-8
• MW: 356.8492
• Purity: >98% (HPLC)
• Formula: C₁₉H₂₁ClN₄O
• SMILES: C1CC(CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N.Cl
• Target: PARP
• Solubility: 10 mM in DMSO

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Niraparib hydrochloride | MK 4827 hydrochloride | MK4827 hydrochloride

Quick Database Links

Gene Symbol

PARP