MK-28

SKU: orb1688178

Description

MK-28 is a selective PERK agonist shown to reduce toxicity and extend survival in a Huntington's disease mouse model. It also demonstrates cytotoxic activity against gastric cancer cells in vitro, supporting its investigation in neurodegenerative and oncology research.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 864388-65-8
• MW: 396.44
• Formula: C₂₄H₂₀N₄O₂
• SMILES: CN(\N=C\c1ccc(O)c(O)c1)c1nc(cc(n1)-c1ccccc1)-c1ccccc1
• Target: Antiviral,PERK
• Solubility: DMSO:10 mg/mL (25.22 mM)

Bioactivity

• In Vivo:
  In R6/2 mice, MK-28 (1 mg/kg; IP, daily for 28 days) increased the survival rate.
• In Vitro:
  In STHdhQ111/111 cells, MK-28 (0-100 μM; 48 h) rescued cells from ER stress-induced apoptosis.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PERK, Antiviral

Compound Identifiers

PubChem CID

135715675