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MK-2206 free base

SKU: orb1942981

Description

MK-2206 free base is a potent, selective, and orally active allosteric Akt inhibitor with IC50 values of 8, 12, and 65 nM for Akt1, Akt2, and Akt3, respectively. It shows activity in breast cancer models with PIK3CA mutations or PTEN loss and has been investigated in both in vitro and in vivo preclinical studies.

Research Area

Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number1032349-93-1
MW407.47
FormulaC25H21N5O
SMILESO=C1NN=C2C=3C=C(C=4C=CC=CC4)C(=NC3C=CN12)C=5C=CC(=CC5)C6(N)CCC6
TargetAutophagy,Akt,Apoptosis

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

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MK-2206 free base (orb1942981)

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